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| 血栓通注射液与氨溴索联合治疗对慢性阻塞性肺疾病伴高凝状态患者血清基质金属蛋白酶9及基质金属蛋白酶组织抑制剂-1表达的影响 | |
| 引用本文： | 程显茂. 血栓通注射液与氨溴索联合治疗对慢性阻塞性肺疾病伴高凝状态患者血清基质金属蛋白酶9及基质金属蛋白酶组织抑制剂-1表达的影响[J]. 中医临床研究, 2021, 0(1): 73-75 |
| 作者姓名： | 程显茂 |
| 作者单位： | 山东省青岛市即墨区第二人民医院 |
| 摘 要： | 目的:探讨血栓通注射液与氨溴索联合治疗对慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Diseases,COPD)伴高凝状态(Hypercoagulable State,HCS)患者凝血功能及基质金属蛋白酶(Matrix Metalloproteinase,MMP)9、基质金属蛋白酶组织... |
| 关 键 词： | 慢性阻塞性肺疾病伴高凝状态 凝血功能 血栓通注射液 基质金属蛋白酶-9 基质金属蛋白酶组织抑制剂-1 |
The effects of the Xueshuantong injection plus ambroxol on the expression levels of serum MMP9 and TIMP-1 of COPD patients with HCS |
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| Cheng Xianmao. The effects of the Xueshuantong injection plus ambroxol on the expression levels of serum MMP9 and TIMP-1 of COPD patients with HCS[J]. Clinical Journal of Chinese Medicine, 2021, 0(1): 73-75 | |
| Authors: | Cheng Xianmao |
| Abstract: | Objective:To explore the effects of the Xueshuantong injection(血栓通注射液)plus ambroxol on coagulation function,and the expression levels of MMP9 and TIMP-1 in COPD patients with HCS.Methods:136 cases in our hospital were selected as the research objects and randomly divided into the control group(66 cases)and the observation group(70 cases).The groups were both given conventional treatment.The control group was supplemented with ambroxol,and the observation group was supplemented with the Xueshuantong injection and ambroxol.Results:After treatment,the PT and APTT in the observation group were significantly higher than those in the control group;FIB,and the expression levels of MMP9 and TIMP-1 in serum in the observation group were significantly lower than those in the control group,both P<0.05.Conclusion:The Xueshuantong injection plus ambroxol can effectively improve the coagulation function of COPD patients with HCS,which may be related to the reduction of the expression levels of serum MMP9 and TIMP-1. |
| Keywords: | COPD with HCS Coagulation function The Xueshuantong injection MMP9 TIMP-1 |
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