Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone |
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Authors: | C Fahlke E H»rd S Hansen |
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Institution: | 1. Department of Psychology, G?teborg University, Haraldsgatan 1, S-413 14, G?teborg, Sweden
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Abstract: | Male Wistar rats bearing intracerebroventricular (ICV) cannulae and with simultaneous access to 6% ethanol and water were
subjected to adrenalectomy (ADX) or sham surgery. ADX decreased ethanol intake. Starting a few days later, the animals received
ICV infusions with 100 μg corticosterone acetate (CORT) with 2-to 3-day intervals for 2 weeks. ICV CORT, but not SC CORT at
the same dose, restored ethanol consumption in ADX rats to preoperative levels, whereas vehicle infusions (propylene, glycol)
did not. Adrenally intact animals, which normally consumed moderate amounts of ethanol (≈0.5 g/kg per day), also showed a
robust effect of ICV infusions of CORT, whereas this facilitatory effect was not observed in high consumers (≈3.0 g/kg per
day). The suppressive effect of ADX on ethanol intake was not reproduced by concurrent and repeated ICV infusions of intracellular
mineralocorticoid (RU 28318) and glucocorticoid (mifepristone) receptor blockers. It is concluded that CORT stimulates alcohol
consumption by acting in the brain, probably by way of neuronal membrane mechanisms. |
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Keywords: | Alcohol drinking Adrenalectomy Corticosterone Drug abuse Mifepristone RU 28318 RU 38486 Interacerebroventricular infusions |
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