静脉注射咪达唑仑与芬太尼用于ICU机械通气患者镇静的临床观察

目的：观察眯达唑仑与芬太尼联合用药对于机械通气患者的镇静效果。方法：对30例ICU机械通气患者给予咪达唑仑和芬太尼联合镇静，维持理想的镇静深度3-4级，观察各项镇静指标。结果：镇静效率（87±8．8）％，咪达唑仑镇静满意期间的平均输注速度为（0．14±0．02）mg·kg^-1·h^-1.镇静期间血压、心率平稳。停药后完全清醒时间为（90±24．8）min，拔除气管插管时间（140±36．6）min。拔管后1h血气正常。结论：咪达唑仑与芬太尼联合用于ICU机械通气患者可获得满意的镇静效果。

Sedative effect of midazolam and fentanyl on ventilated patients in ICU

Objective：To observe the sedative effect of midazolam and fentanyl on the patients with mechanical ventilation in ICU. Methods：Midazolam and fentanyl were given by continuous infusion following a load dose to provide satisfactory sedation in 30 patients requiring mechanical ventilation. Results：The sedation efficiency was （87±8.8）%.The average infusion rate of midazolam during the sedative period was （0.14±0.02）mg .kg^-1 .h^-1, while the heart rates and blood pressures remained stable. The time for recovery of consciousness was （90±24.8）min and the time to extubation was （140±36.6）min. The blood gas analysis was normal in 1 h after extubation. Condusion：Midazolam and fentanyl can provide satisfactory sedation for ICU patients.