β-淀粉样蛋白、tau 蛋白及miR相关指标在血管性痴呆患者中的变化及与严重程度的关系探究

目的 探究β-淀粉样蛋白、tau 蛋白及miR相关指标在血管性痴呆患者中的变化及与严重程度的关系。 方法 选取血管性痴呆患者79例为观察组，同时期的79例体检健康者为对照组。检测与比较2组的血清β-淀粉样蛋白（Aβ1-40及Aβ1-42）、tau 蛋白（tau及p-tau）及miR相关指标（miR-34a、miR-132及miR-135），并比较观察组不同严重程度血管性痴呆患者的上述检测结果，采用Spearman秩相关分析上述β-淀粉样蛋白、 tau 蛋白及miR相关指标与血管性痴呆严重程度的关系。 结果 观察组的血清Aβ1-42、miR-132及miR-135显著低于对照组，血清Aβ1-40、tau 蛋白及miR-34a显著高于对照组，差异有统计学意义（P＜0.001），观察组不同严重程度血管性痴呆患者的上述检测结果比较，差异有统计学意义（P＜0.001），Spearman秩相关分析显示，血清Aβ1-42、miR-132及miR-135与血管性痴呆严重程度呈负相关，血清Aβ1-40、tau 蛋白及miR-34a与血管性痴呆严重程度呈正相关（P＜0.05）。 结论 β-淀粉样蛋白、tau 蛋白及miR相关指标在血管性痴呆患者中呈现显著异常的状态，且与本病的严重程度密切相关，因此在血管性痴呆患者中的检测价值较高。

Investigation into the change of β-amyloid protein,tau protein and miR-related indexes of patients with vascular dementia and their correlation with severity of disease

ObjectiveTo investigate the change of β-amyloid protein, tau protein and miR-related indexes of patients with vascular dementia and their correlation with severity of vascular dementia.MethodsA total of 79 patients with vascular dementia were selected as the observation group, and 79 healthy persons undergoing physical examination during the same period were selected as the control group. Then the serumβ-amyloid protein（Aβ1-40 and Aβ1-42）, tau protein（tau and p-tau） and miR-related indexes（miR-34a, miR-132 and miR-135） of the two groups were detected and compared, and the detection results of observation group with different severity of vascular dementia were compared. Then the correlation between those β-amyloid protein,tau protein, miR-related indexes and severity of vascular dementia was analyzed with Spearman rank correlation analysis.ResultsThe serum Aβ1-42, miR-132 and miR-135 of observation group were significantly lower than those of control group, while the serum Aβ1-40, tau protein and miR-34a were significantly higher than those of control group, suggesing significant differences（P＜0.001）. Those detection results of observation group with different severity of vascular dementia were compared, and there were statistically significant differences（P＜0.001）. The Spearman rank correlation analysis showed the serum Aβ1-42, miR-132 and miR-135 were negatively correlated with severity of vascular dementia, while the serum Aβ1-40, tau protein and miR-34a were positively correlated with severity of vascular dementia（P＜0.05）.ConclusionThe β-amyloid protein, tau protein and miR-related indexes of patients with vascular dementia show significantly abnormal state, and they all have close correlation to the severity of disease. Therefore, their detection value in the patients with vascular dementia is higher.