Disorders of serum omega-3 fatty acid composition in dialyzed patients,and their associations with fat mass |
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| Authors: | Małgorzata Sikorska-Wiśniewska Adriana Mika Tomasz Śledziński Sylwia Małgorzewicz Piotr Stepnowski Bolesław Rutkowski |
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| Affiliation: | 1. Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland;2. Department of Environmental Analysis, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland;3. Department of Pharmaceutical Biochemistry, Medical University of Gdańsk, Gdańsk, Poland;4. Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland |
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| Abstract: | ![]()
Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular mortality. Lipid disorders, a constant feature of CKD, might contribute to this state. The aim of this study was to evaluate n-3 polyunsaturated fatty acids (PUFA) composition in CKD patients treated with dialysis, in comparison to the general population and to assess possible associations between the n-3 PUFA profile and anthropometric variables. Thirty-three prevalent dialysis patients were studied and compared with an age- and sex-adjusted control group of 22 patients. Fatty acid composition in serum was analyzed by gas chromatography with a mass spectrometer detector (GC-MS) and anthropometric measures were assessed by bioimpedance spectroscopy. The fatty acid profile of dialyzed patients was characterized by a significantly lower percentage content of n-3 PUFA. For α-linolenic acid (ALA), it was 0.21?±?0.09% in dialysis patients versus 0.33?±?0.11% in the control group (p?p?p?r?=?.48 (p?r?=?.40 (p?
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| Keywords: | Omega-3 long-chain polyunsaturated fatty acids hemodialysis peritoneal dialysis chronic kidney disease lipid disorders |
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