| Toll样受体:免疫治疗的新靶位 |
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| 引用本文： | 任光圆,晏春根,谢青. Toll样受体:免疫治疗的新靶位[J]. 中国新药与临床杂志, 2004, 23(10): 718-723 |
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| 作者姓名： | 任光圆 晏春根 谢青 |
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| 作者单位： | 1. 绍兴文理学院医学院,浙江,绍兴,312000
2. 上海第二医科大学附属瑞金医院,上海,200025 |
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| 摘 要： | Toll样受体 (Toll likereceptors ,TLRs)是新近发现的模式识别受体 ,能识别病原相关分子模式 ,启动炎性应答通路而调节或控制先天与获得性免疫。以TLRs为靶位 ,抑制或激活TLRs表达或调控TLRs信号通路 ,可能是炎性免疫性疾病新的治疗策略
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| 关 键 词： | 免疫疗法 细胞因子类 配体 信号传导 Toll样受体 |
| 文章编号： | 1007-7669(2004)10-0718-06 |
Toll-like receptors:a new immune therapeutic target |
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| REN Guang-yuan ,YAN Chun-gen ,XIE Qing. Toll-like receptors:a new immune therapeutic target[J]. Chinese Journal of New Drugs and Clinical Remedies, 2004, 23(10): 718-723 |
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| Authors: | REN Guang-yuan YAN Chun-gen XIE Qing |
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| Affiliation: | REN Guang-yuan 1,YAN Chun-gen 1,XIE Qing 2* |
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| Abstract: | The family of Toll-like receptors(TLRs) is a new pattern-recognition receptors(PRRs), which recognize specific pathogen-associated molecular patterns(PAMPs). Recognition of PAMPs by PRRs results in the activation of inflammatory process, which subsequently control the innate and adaptive immune response. It is possible that TLRs will offer validated remediable targets for anti-inflammatory therapeutics by controlling the expression and activation of TLRs. |
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| Keywords: | immune therapy cytokines ligands singal transduction Toll-like receptors |
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