胶束传递系统逆转肿瘤多药耐药的研究进展

肿瘤多药耐药是目前肿瘤治疗的一大障碍。研究采用药物传递系统如胶束、脂质体、纳米粒等, 以逆转多药耐药, 显示其安全可靠, 并具有良好的应用前景。本文重点综述了药物传递系统中的聚合物胶束逆转多药耐药的研究结果及其可能的作用机制。随着研究的深入, 药物传递系统在逆转肿瘤多药耐药的研究领域将发挥更加重要的作用。

Progress in the study of micelle delivery system reversing multidrug resistance

Multidrug resistance (MDR) of cancer cells to anti-tumor drugs remains a major impediment    to successful chemotherapy.  There has been an increasing interest in the studies of the mechanism and reverse of the MDR.  Being a reliable and safe way to reverse MDR, drug delivery systems (DDS) such as micelle,  liposome and nanoparticle, represent a promising prospect both in research and application in recent years.  On the basis of recent studies, the effect and mechanism of micelles on reversing MDR are reviewed.  And it is  anticipated that DDS could contribute greatly to reversing MDR in the future.