二硫化碳接触对粘胶工人血清铜、锌和硒含量的影响

目的 探讨CS₂接触与血清微量元素铜、锌、硒之间的关系,为CS₂接触致心血管系统疾病的毒作用机理提供依据.方法 选择某化纤厂纺丝车间年龄在45岁以下,接触CS₂5年以上76名CS₂作业工作为接触组;在同一工厂棉浆车间选择曾经接触过CS₂但现在已停止CS₂接触5年以上的33名工人作为干预组;从未接触过CS₂的23名工人作为对照组进行流行病学横断面调查.结果 接触组SCu、SZn和SSe含量均低于对照组(P=0.0001);多元逐步回归分析进一步显示,CS₂对SCu、SZn和SSe含量均有负贡献(偏回归系数β分别为-10.4173,-8.973和-15.5098).结论 提示CS₂接触能降低血清铜、锌、硒含量.

The Effects of theExposure to CS2 on Serum Copper, Serum Zinc and Serum Selenium of Workers in the ViscoseRayon Factory

Objective To explore the relation between CS₂ exposure and the trace elements of serum copper,serum zinc,serum selenium,provide the basis for the mechanism of toxicity effects of CS₂ on cardiovascular system disease.Methods In filature workshop of a viscose rayon factory we selected 76 workers with age below 45 years old and touchtime to CS₂ beyond 5 years as exposure group;In cotton plasm workshop of the same factory selected 33 workers who once touched CS₂ but now have been kept away from CS₂ more than 5 years as intervention group;and selected 23 workers who had never touched CS₂ as control one,and the epidemiological cross-sectional investigation was carried out.Results SCu,SZn and S Se of exposure group were all lower than control one(P=0.001).In multivariable stepwise regression,we discovered that exposure to CS₂ caused negative contributions on SCu,SZn,and SSe(partial regression coefficients β are separately -10.417,-8.9735 and-15.5098).Conclusion The results suggested CS₂ exposure could reduce the levels of Scu,SZn and S Se.