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| 非诺贝酸有关物质的HPLC法测定 | |
| 引用本文： | 陆步实,侯敬文,杨大龙,王静,卢定强. 非诺贝酸有关物质的HPLC法测定[J]. 中国医药工业杂志, 2012, 43(5): 372-374 |
| 作者姓名： | 陆步实 侯敬文 杨大龙 王静 卢定强 |
| 作者单位： | 1. 南京工业大学江苏省药物研究所有限公司,江苏南京,210009 2. 南京工业大学药学院,江苏南京,210009 |
| 摘 要： | 建立了高效液相色谱法测定非诺贝酸的有关物质.以苯基硅烷键合硅胶为填充剂,流动相为乙腈-10 mmol/L磷酸二氢钾溶液(1∶1,用磷酸调至pH 2.5),检测波长289 nm.非诺贝酸的最低检测限为1 ng,关键中间体和破坏性试验产生的降解产物和非诺贝酸均能有效分离. |
| 关 键 词： | 非诺贝酸 有关物质 高效液相色谱 测定 |
Determination of Related Substances in Fenofibric Acid by HPLC |
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| LU Bushi , HOU Jingwen , YANG Dalong , WANG Jing , LU Dingqiang. Determination of Related Substances in Fenofibric Acid by HPLC[J]. , 2012, 43(5): 372-374 | |
| Authors: | LU Bushi HOU Jingwen YANG Dalong WANG Jing LU Dingqiang |
| Affiliation: | 1(1.Jiangsu Provincial Institute of Material Medica,Nanjing University of Technology,Nanjing 210009; 2.School of Pharmaceutical Sciences,Nanjing University of Technology,Nanjing 210009) |
| Abstract: | An HPLC method was established for the determination of the related substances in fenofibric acid.A phenyl column was used with the mobile phase of acetonitrile-10 mmol/L potassium dihydrogen phosphate solution (1︰1,adjusted to pH 2.5 with phosphoric acid) at the detection wavelength of 289 nm.The low limit of detection was 1 ng.The key intermediate and degradation products generated by destructive experiments could be separated effectively with fenofibric acid. |
| Keywords: | fenofibric acid related substance HPLC determination |
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