甘露醇甘油注射液对Beagle犬实验性颅内高压的影响

【目的】探讨甘露醇甘油注射液对实验性Beagle犬颅内高压的影响。【方法】取健康合格Beagle犬48只，按性别体重分层随机分为8组，每组6只，分别为正常对照组（0．9％氯化钠注射液4mL／kg）；模型组（40只），注射自体血凝块建立颅内高压模型，侧脑室插管接压力感受器监测颅内压，其中有模型对照组（0．9％氯化钠注射液4mL／kg）、甘露醇甘油注射液2mL／kg组、甘露醇甘油注射液4mL／kg组、甘露醇甘油注射液8mL／kg组、复方甘露醇注射液4mL／kg组、20％甘露醇4mL／kg组、10％甘油氯化钠注射液4mL／kg组。观察甘露醇甘油注射液对颅内压的影响。【结果】静脉滴注甘露醇甘油注射液（2mL／kg、4mL／kg、8mL／kg）均能显著降低Beagle犬脑血肿诱导的颅内压升高，且呈剂量依赖关系；4mL／kg甘露醇甘油注射液降颅内压作用与同剂量的20％甘露醇和复方甘露醇注射液相当，且作用时间维持较长。甘露醇甘油注射液对肾功能、电解质等各指标的影响与对照组比较无明显差异（P〉0．05）。【结论】甘露醇甘油注射液能显著降低颅内压，其作用强度与20％甘露醇和复方甘露醇注射液作用相当，降颅内压维持时间较长，且未见明显肾功能损害和电解质紊乱。

Effects of Mannitol and Glycerol Injection on Experimental Beagle Dog Intracranial Hypertension

Obj ective]To study the influence of the mannitol and glycerin inj ection (containing 1 5% mannitol and 1 5% glycerin) on intracranial hypertension of experimental beagle dogs.Methods]48 health qualified beagle dogs were randomly divided according to the sex and body weight into eight groups (6 in each ):the normal control group (0.9% sodium chloride injection 4 ml/kg);the model group (40 )were injected with autologous blood clots to establish model of intracranial hypertension,intracerebroventricular cannula was connected with baroreceptor to monitor intracranial pressure,including the model control group (0.9% sodium chloride injection 4 mL/kg),the group of mannitol and glycerin inj ection 2 mL/kg,the group of mannitol and glycerin inj ection 4 mL/kg,the group of mannitol and glycerin injection 8 mL/kg,the group of compound mannitol injection 4 mL/kg ,the group of 20% mannitol 4 mL/kg and the group of 1 0% glycerol and sodium chloride inj ection 4 mL/kg.The effect of mannitol and glycerin inj ection on intracranial pres-sure was observed.Results]Intravenous drip of mannitol and glycerin inj ection (2 mL,4 mL,8 mL/kg)can significantly reduce the Beagle canine intracranial pressure which was induced by cerebral hematoma,and there was a dose dependent relationship therewith;The effect of reducing intracranial pressure of 4 mL/kg mannitol and glycerin injection was equivalent to that of the same dose of 20%mannitol and compound mannitol inj ection,and the action time was longer.There was no significant difference between the effects of mannitol and glycerin injection on renal function and electrolyte compared with the control group (P>0.05).Conclusion]The manni-tol and glycerin injection could significantly reduce the intracranial pressure,and are equivalent to the same efficiency of 20%mannitol and compound mannitol inj ection with a long duration of reducing intracranial pressure without obvious renal impairment and electrolyte disorder.