胎盘多肽在晚期恶性肿瘤化疗中的作用

目的]探讨胎盘多肽注射液应用于晚期恶性肿瘤化疗的临床效果及对患者免疫功能的影响.方法]将本院肿瘤内科收治的90例不能接受手术治疗的晚期恶性肿瘤患者分为观察组和对照组两组,每组各45例,两组患者均给予常规化疗方案,观察组加用胎盘多肽注射液治疗,21 d为一个周期,连续用药治疗4个周期,观察两组患者的临床疗效及免疫学指标差异.结果]观察组的缓解率为40%(18/45)显著高于对照组的20%(9/45),且两组相比较差异有显著性(P<0.05),两组患者的有效率比较差异无显著性(P>0.05).化疗前两组患者的KPS评分相比较差异无显著性(P>0.05),治疗后两组患者的KPS评分均较治疗前显著提高(P<0.05),观察组较对照组提高更加显著(P<0.05).化疗前两组患者的T淋巴细胞亚群值比较差异无显著性(P>0.05),治疗后对照组的CD4+细胞水平、CD4+/CD8+显著低于观察组(P<0.05).化疗前两组患者的体液免疫指标比较差异无显著性(P>0.05),治疗后对照组的IgG、IgM显著低于观察组(P<0.05).观察组的恶心、呕吐(60%)、口腔黏膜炎(11.11%)、外周神经毒性(13.33%)发生率显著低于对照组,且差异具有显著性(P<0.05).结论]胎盘多肽注射液应用于晚期恶性肿瘤化疗能够改善患者近期疗效、提高患者体能状况、改善患者的免疫水平,降低不良反应发生率.

Role of Placental Peptide Injection in Chemotherapy of Advanced Malignant Tumor

Objective]To analyze he clinical efficacy of placenta polypeptide inj ection used in advanced ma-lignant tumor chemotherapy on the immune function of patients.Methods]90 cases of advanced malignant tumor undergoing surgery patients admitted to the department of medical oncology at our hospital were divided into treatment group and control group with 45 cases in each.Both groups of patients were given conventional chemotherapy,and the treatment group received placenta polypeptide inj ection treatment 21 days a cycle medi-cation for a four-cycle period.Clinical efficacy and immunological index difference between the two groups of patients were observed.Results]In the treatment group,remission rate was 40%,which was significantly higher than that the remission rate of 20% in the control group.The difference was statistically significant(P<0.05).The difference between the efficacies of the two groups of patients did not have a statistical signifi-cance (P >0.05).Prior to chemotherapy,KPS scores of the patients in the two groups had no statistical sig-nificant differences (P >0.05).KPS score of the patients in the two groups increased significantly after treat-ment compared to before (P <0.05);the treatment group improved more significantly (P <0.05).Before chemotherapy,the difference between T lymphocyte subsets between the two groups of patients was not sta-tistically significant (P >0.05).After treatment,the levels of CD4+ cells and CD4+/CD8+ in the control group were significantly lower than those of the treatment group (P <0.05 ).Before chemotherapy,the difference between humoral immune indexes in two groups of patients showed no statistical significance (P >0.05).IgG and IgM of the control group were significantly lower than that of treatment group (P <0.05)after treatment..The treatment group's cases of nausea and vomiting (60%),oral mucositis (11.11%),and periph-eral neurotoxicity (13.33%)were significantly lower those of the control group;the difference was statistically significant (P <0.05).Conclusion]Placenta polypeptide and application in chemotherapy for advanced malig-nant tumor can improve clinical efficacy and improve the physical condition of patients and immunity of the pa-tients as well as reduce the incidence of adverse reactions.