Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis |
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| Authors: | McGuire Carolann Chan Weng C Wakelin Derek |
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| Affiliation: | School of Life and Environmental Sciences, University of Nottingham, University Park, United Kingdom. |
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| Abstract: | Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites. |
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