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| 金铁锁体外抗氧化活性研究 | |
| 引用本文： | 袁琳,马银海,尹震花,王微,顾雪竹,康文艺.金铁锁体外抗氧化活性研究[J].中国实验方剂学杂志,2012,18(6):109-112. |
| 作者姓名： | 袁琳 马银海 尹震花 王微 顾雪竹 康文艺 |
| 作者单位： | 1. 昆明学院化学科学与技术系,昆明,650214 2. 河南大学中药研究所,河南开封,475004 3. 中国中医研究院中药研究所,北京,100700 |
| 基金项目： | 教育部科学技术研究重点项目(210203) |
| 摘 要： | 目的:研究金铁锁体外抗氧化活性.方法:采用清除采用清除二苯代苦味酰基( DPPH)自由基、清除2,2'-连氨-(3-乙基苯并噻唑啉-6-磺酸)二氨盐](ABTS)自由基及铁离子还原/抗氧化能力(FRAP)测定法,对金铁锁体外抗氧化活性进行评价,并阳性对照没食子酸丙酯(PG)、丁基羟基茴香醚(BHA)和二丁基羟基甲苯(BHT)比较.结果:金铁锁3个提取物体外抗氧化活性均弱于阳性对照PG,BHA,BHA.在3个提取物中,金铁锁乙酸乙酯提取物清除ABTS自由基(IC50=40.54mg·L-1)及还原Fe3+的能力TEAC=(696.9±2.42) μmol·g-1]较强；正丁醇清除ABTS自由基(IC50=83.38 mg· L-1)及还原Fe3+的能力TEAC =(166.1±1.06) μmol· g-1]次之,石油醚提取物最弱.结论:金铁锁乙酸乙酯部位体外抗氧化活性较强. |
| 关 键 词： | 金铁锁 抗氧化活性 二苯代苦味酰基 [2 2’-连氨-(3-乙基苯并噻唑啉-6-磺酸)二氨盐] 铁离子还原/抗氧化能力 |
| 收稿时间： | 2011/11/22 0:00:00 |
Antioxidant Activity of Psammosilene Tunicoides in vitro |
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| YUAN Lin,MA Yin-hai,YIN Zhen-hu,WANG Wei,GU Xue-zhu and KANG Wen-yi.Antioxidant Activity of Psammosilene Tunicoides in vitro[J].China Journal of Experimental Traditional Medical Formulae,2012,18(6):109-112. | |
| Authors: | YUAN Lin MA Yin-hai YIN Zhen-hu WANG Wei GU Xue-zhu and KANG Wen-yi |
| Institution: | Chemical Science and Technology Department, Kunming University, Kunming 650214, China;Chemical Science and Technology Department, Kunming University, Kunming 650214, China;Institute of Chinese Materia, Henan University, Kaifeng 475004, China;Institute of Chinese Materia, Henan University, Kaifeng 475004, China;Institute of Chinese Materia Medica, Traditional Chinese Medical Research Institute, Beijing 100700, China;Institute of Chinese Materia, Henan University, Kaifeng 475004, China |
| Abstract: | Objective:To study the antioxidant activity Psammosilene tunicoides in vitro.Method:Antioxidant activities of P.tunicoides were evaluated by the 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging,2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid]diamonium salt(ABTS) radical scavenging and ferric reducing antioxidant power(FRAP) assay.Results were compared with that of positive controls PG,BHA and BHT.Result:Antioxidant activity of three extracts from P.tunicoides was weaker than that of the positive control PG,BHA and BHA.In the three extracts,Antioxidant activities of ethyl acetate extract was good.ABTS radical scavenging(IC50=40.54 mg·L-1) and ferric reducing antioxidant power 2.42) μmol·g-1] of ethyl acetate extract were strong,followed by the ABTS radical scavenging(IC50=83.38 mg·L-1) and ferric reducing antioxidant power ·g-1] of n-butanol extract,petroleum ether extract was the weakest.Conclusion:Ethyl acetate extract of P.tunicoides had strong antioxidant activity. |
| Keywords: | Psammosilene tunicoides W C Wu et C Y Wu antioxidant activity DPPH ABTS FRAP |
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