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| Ang-2和VEGF在大肠癌中的表达及其意义 | |
| 引用本文： | 赵德芳,仝林虎. Ang-2和VEGF在大肠癌中的表达及其意义[J]. 内蒙古医学杂志, 2011, 43(9): 1030-1033,1152 |
| 作者姓名： | 赵德芳 仝林虎 |
| 作者单位： | 内蒙古医学院附属医院普外科,内蒙古呼和浩特,010050 |
| 摘 要： | 目的：探讨血管生成素2（Ang-2）和血管内皮生长因子（VEGF）在大肠癌发生、发展、浸润、转移及血管生成中的调节作用。方法：运用免疫组织化学法分别检测85例大肠癌组织,24例癌旁肠组织,24例正常肠组织中Ang-2和VEGF的表达情况。根据CD34的表达分别计算大肠癌组织、癌旁肠组织及正常肠黏膜的微血管密度。结果：原发性大肠癌组织中Ang-2表达阳性率为63%（54/85）,VEGF表达阳性率为80%（65/85）,两者表达部位相似。在癌组织中,Ang-2和VEGF表达增高也可见MVD增高,但在癌旁组织中MVD不与两者表达水平平行。Ang-2、VEGF、MVD均与大肠癌组织分化程度、Dukes分期、转移密切相关。在24例癌旁组织中Ang-2和VEGF分别有10例和15例表达阳性,表达强度与癌组织无区别。在24例正常黏膜中,Ang-2几乎不表达,有10例组织呈VEGF弱表达。结论：Ang-2和VEGF均与大肠癌血管生成有关,两者协同作用,与大肠癌浸润、转移有关。Ang-2在肿瘤组织中特异性表达,可能与肿瘤的发生有关。 |
| 关 键 词： | 大肠癌 血管生成素2 血管内皮生长因子 血管生成 |
The Expression and Significance of Ang-2 and VEGF in Colorectal Cancer |
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| ZHAO De-fang,TONG Lin-hu. The Expression and Significance of Ang-2 and VEGF in Colorectal Cancer[J]. Inner Mongolia Medical Journal, 2011, 43(9): 1030-1033,1152 | |
| Authors: | ZHAO De-fang TONG Lin-hu |
| Affiliation: | ZHAO De-fang,TONG Lin-hu(Department of General Surgery,The Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010050 China) |
| Abstract: | Objective:To analyze the expression of Ang-2 and VEGF in colorectal cancer and their relation to angiogenesis.Methods:Tissue sections of 85 colorectal cancers were examined by immunohistochemistry for the expression of Ang-2 and VEGF.Microvessel density(MVD) was counted by endothelial cells immunostained with CD34 antibody.Results:Ang-2 and VEGF was detected in 63%(54/85) and 80%(65/85) of colorectal cancer,respectively.They were expressed at similar position of the same tissue slice.The level of Ang-2 and ... |
| Keywords: | Colorectal cancer Angiopoietin-2 Vascular endothelial growth factor Angiogenesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |