| 系膜细胞外基质与糖尿病肾病 |
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| 引用本文： | 魏聪,吴以岭,冯书文,高怀林,贾振华,袁国强. 系膜细胞外基质与糖尿病肾病[J]. 辽宁中医药大学学报, 2008, 10(1): 8-10 |
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| 作者姓名： | 魏聪 吴以岭 冯书文 高怀林 贾振华 袁国强 |
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| 作者单位： | 河北以岭医药研究院,河北,石家庄,050035;河北医科大学附属以岭医院,河北,石家庄,050091 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，河北省科学技术研究与发展计划 |
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| 摘 要： | 细胞外基质进行性积聚是导致糖尿病肾病发生、发展的重要病理基础.通过对细胞外基质成分及代谢相关途径包括糖代谢紊乱引发的葡萄糖转运蛋白表达、蛋白激酶C通路激活、糖激化终末产物及多元醇通路激活;细胞因子影响,以系统阐明糖尿病肾病发病过程中影响系膜细胞外基质的机制.
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| 关 键 词： | 糖尿病肾病 细胞外基质 |
| 文章编号： | 1673-842X(2008)01-0008-03 |
| 修稿时间： | 2007-07-25 |
Extracellular Matrix and Diabetic Nephropathy |
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| WEI Cong,WU Yi-ling,FENG Shu-wen,GAO Huai-lin,JIA Zhen-hua,YUAN Guo-qiang. Extracellular Matrix and Diabetic Nephropathy[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2008, 10(1): 8-10 |
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| Authors: | WEI Cong WU Yi-ling FENG Shu-wen GAO Huai-lin JIA Zhen-hua YUAN Guo-qiang |
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| Abstract: | It was the important pathologic basis of diabetic nephropathy that extracellular matrix gradually accumulation.This article was systematically clarified the pathogenesis mechanism of diabetic nephropathy which affected composition and metabolism of the extracellular matrixi,ncluding the expression of glucose transporter proteinp,athway activation of PKCA,GEsP,P caused by glucose metabolic disorder and the impact of cytokines. |
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| Keywords: | diabetic nephropathy extracellular matrix |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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