载脂蛋白E在系统性红斑狼疮患者中的表达及其临床意义

目的：检测系统性红斑狼疮（SLE）患者血清中载脂蛋白 E（ApoE）水平变化，探讨其临床意义。方法选取2012年8月至2013年5月于河北北方学院附属第二医院院进行诊治的47例S L E患者及40例健康者作为研究对象，应用酶联免疫吸附试验（ELISA）检测血清中ApoE水平，根据不同临床指标进行分组并进行统计学分析。结果与健康对照组相比，SLE患者组ApoE总体表达水平升高[（15．2±4．4）pg/mL vs ．（8．6±3．3） pg/mL ，P＜0．05]，其中活动组患者 ApoE较非活动组患者相比升高更为明显[（18．3±6．1）pg/mL vs ．（14．2 ± 5．7） pg/mL ，P＜0．05]；狼疮性肾炎组和非狼疮性肾炎组血清中 ApoE水平较健康对照组升高（P＜0．05），但两组间差异无统计学意义（P＞0．05）；抗双链DNA（ds-DNA）抗体阳性组患者血清中ApoE水平较抗ds-DNA抗体阴性组患者明显升高[（17．9 ± 5．8）pg/mL vs ．（13．9 ± 4．7） pg/mL ，P＜0．05]。结论 ApoE可作为反映SLE患者病情活动的有效指标，为疾病免疫治疗提供一定的理论依据。

Expression and clinical significance of apolipoprotein E in patients with systemic lupus erythematosus

Objective To explore the expression level and clinical significance of apolipoprotein E （Apo E） in patients with systemic lupus erythematosus （SLE） .Methods From Aug .2012 to May 2013 ,47 SLE patients and 40 healthy controls in the Second Affiliated Hospital of Hebei North University were enrolled and detected for serum ApoE level by using enzyme linked immunosorbent assay （ELISA ） .Patients were divided into different groups ac-cording to clinical indicators ,and data were statistically analyzed .Results Compared with healthy controls ,ApoE level of SLE patients were increased [（15 .2 ± 4 .4）pg/mL vs .（8 .6 ± 3 .3）pg/mL ,P〈0 .05）] ,and activity SLE pa-tients higher more pronounced than inactivity [（18 .3 ± 6 .1）pg/mL vs .（14 .2 ± 5 .7）pg/mL ,P〈0 .05] .ApoE levels of patients with or without nephritis were higher than healthy controls （P〈0 .05） ,but no statistically different be-tween the two patient groups （P〉 0 .05） .ApoE of anti-dsDNA antibody positive SLE patients were marked in-creased ,compared with anti-dsDNA antibody negative patients [（17 .9 ± 5 .8）pg/mL vs .（13 .9 ± 4 .7）pg/mL ,P〈0 .05）] .Conclusion ApoE could be used as an effective indicator of disease activity in patients with SLE ,and provide certain theoretical basis for immunotherapy of disease .