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可溶性血管间黏附分子1(sVCAM-1)、C反应蛋白(CRP)与急性冠状动脉综合征(ACS)相关性研究
引用本文:王志斌,赵令时,魏玉萍. 可溶性血管间黏附分子1(sVCAM-1)、C反应蛋白(CRP)与急性冠状动脉综合征(ACS)相关性研究[J]. 中国医药指南, 2009, 7(3): 11-12
作者姓名:王志斌  赵令时  魏玉萍
作者单位:[1]山东省潍坊医学院,山东潍坊261042 [2]山东省潍坊市人民医院心内二科,山东潍坊261041 [3]山东省潍坊滨海经济开发区人民医院,山东潍坊262737
摘    要:目的探讨可溶性血管间黏附分子1(sVCAM-1)、C反应蛋白(CRP)等相关指标在急性心肌梗死患者及不稳定型心绞痛患者体内表达及其临床意义。方法通过ELISA法分别检测急性心肌梗死患者、稳定型心绞痛患者及健康查体者人体内sVCAM-1、hs-CRP水平并对各指标作组间比较以分析三组之间差异。结果两指标以急性心肌梗死患者体内水平为最高,与不稳定型心绞痛患者及健康查体者之间的差异有显著性(P<0.01);不稳定型心绞痛组两指标较正常对照组差异有显著性(P<0.01)。结论不稳定型心绞痛患者、心肌梗死患者血清sVCAM-1、CRP异常表达,sVCAM-1、CRP参与了心血管疾病的形成与发展。

关 键 词:可溶性血管间黏附分子1  C反应蛋白  不稳定型心绞痛  急性心肌梗死

The Comparative Study of Soluble Vascular Cellular Adhesion Molecule-I, C-Reactive Protein with Acute Coronary Syndrome
WANG Zhi-Bin,ZHAO Ling-Shi,WEI Yu-Ping. The Comparative Study of Soluble Vascular Cellular Adhesion Molecule-I, C-Reactive Protein with Acute Coronary Syndrome[J]. Guide of China Medicine, 2009, 7(3): 11-12
Authors:WANG Zhi-Bin  ZHAO Ling-Shi  WEI Yu-Ping
Affiliation:1 Weifang Medical University Weifang Shandong 261042, China; 2 Department of Cardiology, Weifang Peoples Hospital, Weifang 261041, China;3 Binhai Economy Development District Peoples Hospital, Weifang 262737, China)
Abstract:Objective To investigate and compare the expressions of soluble vascular celllar adhesion molecule-l,C-reactive protein with acute myocardial infarction and unstable angina pectoris their clinical significances. Methods The levels of sVCAM-1 and CRP in acute myocardial infarction group,unstable angina pectorics group and normal control group were respectively measured by ELISA,and compared among them.Results The levels of sVCAM-1 and CRP were highest in the acute myocardial infarction group compared with those in the unstable angina pectoris group and normal control group with significant difference (P〈0.01).The difference between unstable angina pectoris group and control group was significant (P〈0,01).Conclusion There were abnormal expressions of sVCAM-1 and CRP in the patients with unstable angina pectoris or acute myocardial infarction, sVCAM-1 and CRP participated in the formation and development of cardiovascular diseases.
Keywords:sVCAM-1  CRP  Untable angina pectoris  Acute myocardial infarction
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