| 胃癌组织中ras基因点突变和病人预后关系的研究 |
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| 引用本文： | 王俊茹,刘为纹,邓国仁,吕有勇,王欣. 胃癌组织中ras基因点突变和病人预后关系的研究[J]. 第三军医大学学报, 1993, 0(6) |
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| 作者姓名： | 王俊茹 刘为纹 邓国仁 吕有勇 王欣 |
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| 作者单位： | 第三军医大学西南医院消化科，第三军医大学西南医院消化科，北京市肿瘤研究所，北京市肿瘤研究所，北京市肿瘤研究所 630038，630038 |
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| 摘 要： | 本文使用PCR—RFLP方法分析了42例福尔马林固定、石蜡包埋胃癌组织中c-Ha-Yas基因第12位和61位密码子、N-ras基因第12位密码子、K-ras基因第12位和第13位密码子的点突变。发现14例(33.3％)有c-Ha-ras基因第12位密码子的点突变、2例(4.8％)有K-ras基因第12位密码子的点突变,且点突变与胃癌患者的预后有关。我们认为,ras基因点突变的检测可成为临床医生判断胃癌病人预后有价值的指标。
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| 关 键 词： | 胃肿瘤 癌基因蛋白P_(21)突变 PCR-RFLP |
A study on the relationship of point mutation of ras oncogenes with prognosis of patients with gastric cancer |
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| Wang Junru,Liu Weiwen,Deng Guoren,Li Youyong,Wang Xin. A study on the relationship of point mutation of ras oncogenes with prognosis of patients with gastric cancer[J]. Acta Academiae Medicinae Militaris Tertiae, 1993, 0(6) |
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| Authors: | Wang Junru Liu Weiwen Deng Guoren Li Youyong Wang Xin |
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| Abstract: | Point mutation of c-Ha-ras at coden 12 and 61. of N-ras coden 12, and of K-ras at coden 12 and 13 was observed in the formalin-fixed, parraffin-embedded tissue specimens of 42 cases of gastric cancer with PCR-RFLP. It was found that point mutation of c-Ha-ras at coden 12 was found in 14 cases out of the 42 (33. 3%) and that of K-ras at coden 12 in 2 cases (4. 8%). Statistical analysis showed that the point mutation of ras oncogenes plays an important role in the prognosis of the patients with gastric cancer. |
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| Keywords: | stomach neoplasms oncogene protein P_(21)(ras) mutation PCR-RFLP |
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