349例泛影葡胺不良反应报告分析

目的通过总结与分析泛影葡胺不良反应，为临床合理用药提供参考。方法对2003年至2008年湖南省药品不良反应监测中心收集的349例泛影葡胺不良反应报告进行统计分析。结果泛影葡胺所致不良反应的临床表现多样，能导致多个系统一器官不良反应发生。349例患者中，男性发生率高于女性；20～69岁人群发生不良反应为314例（占89．97％）；胃肠系统损害最常见（31．13％），其次为皮肤及其附件损害（22．42％）、呼吸系统损害（15．97％）、全身性损害（11．29％）和中枢及外周神经系统损害（7．90％）。结论临床必须重视泛影葡胺不良反应的监测，以减少或避免严重药品不良反应的发生。

Analysis of 349 Cases Reports of ADRs Caused by Meglumine Diatrizoate

Objective To summarize the occurrences of adverse drug reacdons（ADR） caused by meglumine diatrizoate acid, and to guide the rational usage of meglumine diatrizoate in clinical practice in the future. Methods By arranging, classifying and analyzing the reports of ADRs induced by meglumine diatrizoate used through the Date Base created by Hunan center for ADR monitoring from 2003 to 2008. Results meglumine diatrizoate could cause multi-system and multi-organ ADRs with wide variety of clinical manifestations. Of the 349 ADR patients, ADR incidence rate was higher in males than in females, the age of 314（89.97%） ADR patients were 20- 69 years; and 193（31.13%） case had severe lesions of the gastro-intestinal sys-tem, followed by lesions of the skin and the appendants（139 cases,22.42%）、the respiratory system （99 cases,15.97%）,the body as a whole-general disorders（70 cases,11.29%） and the center peripheral nervous system（49 cases,7.90%）. Conclusiorl ADRs caused by meglumine diatrizoate acetrizoic acid should be monitored so as to reduce or avoid severe ADRs.