羟苯磺酸钙对维持性腹膜透析患者微炎症状态的影响

目的 探讨羟苯磺酸钙对尿毒症维持性腹膜透析患者微炎症状态的影响.方法 选择笔者医院肾病内科尿毒症维持性腹膜透析患者64例,随机分为腹膜透析治疗对照组（A组）和羟苯磺酸钙治疗观察组（B组,羟苯磺酸钙治疗,0.5g,3次/天）,另选择笔者医院体检中心32例健康志愿者作为正常组（C组）.其中A、B组患者行常规持续不卧床腹膜透析（CAPD）治疗,治疗时间12周.观察治疗前后3组受试者肾功能、血清超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白介素-8（IL-8）、白介素-6（IL-6）,以及营养学指标血白蛋白（Alb）、前白蛋白（PA）、血红蛋（Hb）、改良主观综合性营养评估（SGA）评分的变化.结果 与C组相比较,A组、B组患者的炎症因子hs-CRP、IL-6、TNF-α水平均上升（P＜0.05）,与A组比较,B组患者的炎症因子水平降低.而与C组相比较,A组、B组患者营养学指标（Alb、PA、Hb）均有所下降（P＜0.05）,SGA评分有所上升（P＜0.05）;羟苯磺酸钙液治疗12周后,B组患者Alb、PA、Hb水平上升更明显,差异均有统计学意义（P＜0.05）,B组SGA评分下降更明显（P＜0.05）.结论 腹膜透析患者存在微炎症状态,羟苯磺酸钙治疗可在一定程度上改善腹膜透析患者的微炎症状态,并改善患者的营养状态.

Effects of Calcium Dobesilate on Microinflammation State of Maintenance Peritoneal Dialysis Patients

Objective To compare the microinflammation states between peritoneal patients and the healthy adults, and to observe the changes of microinflammation states and nourishment state in maintenance peritoneal dialysis patients after treatment by calcium dobe silate for 12 weeks. Methods The study included 64 maintenance peritoneal dialysis patients who were followed - up in our hospital. All patients were randomly divided into control group （Group A, regular peritoneal dialysis treatment） and treatment group（ Group B, peritoneal dialysis and calcium dobesilate treatment） , while 32 normal medical examination adults were selected as healthy control group（ Group A, no treatment）. Serum hs - CRP, IL - 6, IL - 8, TNF - a, albumin （Alb） , prcalbumin （ PA ） , hemoglobin （Hb） , a modified quantitative subjective global assessment of nutrition（SGA） scores were measured at the experiment onset and 12 weeks later. Results Patients＇ serum hs - CRP, IL -6,IL -8,TNF - a,SGA scores in Group A and Group B were all higher than that in Group A （P 〈0.05） , and Alb, PA, Hb levels in Group A and Group B were all lower than that in Group A （ P 〈 0. 05 ）. Compared to experiment onset, hs - CRP, IL -6, IL -8,TNF -a, SGA scores were obviously decreased in Group B after 12 weeks （P 〈 0.05 ） , and Alb, PA, Hb levels were significantly increased （P 〈0.05）. Conclusion There was microinflammatory state in maintenance peritoneal dialysis patients. Calcium do besilate can improve the microinflammatory state of maintenance peritoneal dialysis patients.