晚期非小细胞肺癌患者化疗时应用护肝药物的临床意义分析

目的 研究预防性使用护肝药物在晚期非小细胞肺癌患者化疗过程中,是否使肝功能损伤发生率降低.方法 回顾性分析在浙江省肿瘤医院就诊138例晚期非小细胞肺癌患者,化疗前是否接受预防性使用护肝药物,用卡方检验肝功能受损是否存在差异,观测肝功能的损伤与哪些因素相关.结果 预防性使用护肝药物可使肝功能受损发生率降低（P=0.00）.化疗周期数与肝功能损伤相关（P=0.01）.结论 晚期非小细胞肺癌患者化疗过程中,预防性使用护肝药物的患者可有效的降低肝功能损伤.

Clinical Analysis of Application of Protecting Liver Drugs in Advanced Non-small Cell Lung Cancer Patients who Receiving Chemotherapy

Objective To study whether prophylactic use of the protection liver drugs can reduce the incidence of liver dysfunction in advanced non-small lung cancer patients when chemotherapy.Methods We retrospectively reviewed 138 cases advanced non-small cell lung cancer patients in Zhejiang Cancer Hospital.Whether prophylactic use of protection liver drugs before chemotherapy was studied.Chi-square test was used to analysis difference in liver dysfunction between whether the prophylactic use of protection liver drugs.What factors associated with liver injury were observed.Results Prophylactic use of liver drugs could reduce the incidence of impaired liver function （P =0.00,P ＜ 0.05）.Chemotherapy cycles had a relationship with liver dysfunction （P =0.01,P ＜ 0.05）.Conclucion Receiving protection liver drugs can effectively reduce incidence of impaired liver function in advanced non-small lung cancer patients when chemotherapy.