Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection |
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| Authors: | Shayla Hesse Frederick H. Neill Mary K. Estes Sreejesh Shanker B. V. Venkataram Prasad Jennifer Ferreira Robert L. Atmar |
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| Affiliation: | aDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA;bDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA;cDepartment of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA;dEMMES Corporation, Rockville, Maryland, USA |
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| Abstract: | The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74.5% and >95%, respectively, for identifying GI.1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route followed by an oral live GI.1 norovirus challenge. |
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