PEEP ventilation does not cause humorally mediated cardiac output depression in pigs |
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| Authors: | J. E. Berglund E. Haldén S. Jakobson J. Svensson |
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| Affiliation: | (1) Present address: Department of Anaesthesiology and Intensive Care and Department of Clinical Research II, University Hospital, S-75185 Uppsala, Sweden;(2) Department of Clinical Chemistry, Danderyd Hospital, Stockholm, Sweden |
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| Abstract: | ![]()
Objective This study was designed to see if humorally mediated negative inotropism contributes to the cardiac output (CO) depression seen during positive endexpiratory pressure (PEEP) ventilation.Design 8 pairs of piglets were used and a combined blood circulation was established between the two animals in each pair. One animal was ventilated with a PEEP of 15 cmH2O (donor) and the other was ventilated without PEEP (recipient).Measurement and results CO and stroke volume deteriorated in the donors by 32% and 44%, respectively, while no change was seen in the recipients.Conclusion As humorally mediated negative inotropism during PEEP ventilation has earlier been demonstrated in dogs, the results suggest that this mechanism might be species-dependent. |
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| Keywords: | Cardiac output Negative inotropism Mechanical ventilation Positive end-expiratory pressure Cross circulation |
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