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| 肝细胞癌免疫治疗的现状与挑战 | |
| 引用本文： | 曲建慧,张翠红,李若然,陆荫英. 肝细胞癌免疫治疗的现状与挑战[J]. 传染病信息, 2016, 0(4). DOI: 10.3969/j.issn.1007-8134.2016.04.001 |
| 作者姓名： | 曲建慧 张翠红 李若然 陆荫英 |
| 作者单位： | 解放军第三〇二医院肝脏肿瘤诊疗与研究中心, 北京,100039 |
| 基金项目： | 国家自然科学基金面上项目(81470865)；解放军第三〇二医院院长创新基金课题(KJGG2015003)；[基金项目]国家自然科学基金面上项目(81470865)；解放军第三〇二医院院长创新基金课题(KJGG2015003)； |
| 摘 要： | 免疫疗法是目前肿瘤治疗的一种新方法,应用前景广阔,在治疗相关毒性和疗效方面较传统疗法均具有明显优势。免疫检查点抑制、克服肿瘤免疫逃逸和重建抗肿瘤免疫机制是肿瘤免疫治疗的关键。在肝细胞癌中,免疫治疗尚处于初级阶段,免疫治疗单独或联合其他治疗方法可能有利于控制肿瘤进展,但总体疗效仍然有限。本文结合免疫治疗在肿瘤中的研究和应用进展,分析了肝细胞癌免疫治疗研究现状以及面临的挑战。 |
| 关 键 词： | 癌,肝细胞 免疫系统 免疫疗法 |
Current status and challenges of immunotherapy in hepatocellular carcinoma |
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| QU Jian-hui,ZHANG Cui-hong,LI Ruo-ran,LU Yin-ying. Current status and challenges of immunotherapy in hepatocellular carcinoma[J]. Infectious Disease Information, 2016, 0(4). DOI: 10.3969/j.issn.1007-8134.2016.04.001 | |
| Authors: | QU Jian-hui ZHANG Cui-hong LI Ruo-ran LU Yin-ying |
| Abstract: | Tumor immunotherapy is a promising, novel treatment strategy that may lead to improvements in both treatment-associated toxicity and outcome. The key point for tumor immunotherapy is to inhibit immune checkpoint,overcome tumor immune escape and reconstruct anti-tumor immune mechanism. For hepatocellular carcinoma (HCC), immunotherapy is still in an early stage of development. Immunotherapy, alone or in combination with other therapy methods, might provide an effective control of tumor cell growth. However, the overall therapeutic efficacy is still limited. Here, this review summarized current status and challenges of immunotherapy in hepatocellular carcinoma by combination of its progress of research and application. |
| Keywords: | carcinoma,hepatocellular immune system immunotherapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |