痛泻宁颗粒联合美沙拉秦口服治疗溃疡性结肠炎的疗效观察

目的：观察痛泻宁颗粒联合美沙拉秦颗粒治疗轻度、中度溃疡性结肠炎（U C ）的临床疗效。方法选择380例内镜检查临床确诊的轻度、中度U C患者，将其分为观察组（190例）与对照组（190例）。观察组给予痛泻宁颗粒联合美沙拉秦颗粒口服治疗，对照组予美沙拉秦颗粒口服治疗，疗程均为8周。分别统计两组的总有效率，并测定两组患者治疗前、后血清基质金属蛋白酶‐2（MMP‐2）与基质金属蛋白酶‐9（MMP‐9）水平，免疫组织化学SP法检测肠道标本S100钙结合蛋白A12（S100A12）及晚期糖基化终末产物受体（RAGE）的表达。结果观察组总有效率为94．74％，对照组为89．47％，差异有统计学意义（P＜0．01）；治疗后，两组MMP‐2、MMP‐9表达水平均降低，且观察组低于对照组，差异有统计学意义（P＜0．01）。治疗后，观察组RAGE及S100A12表达水平降低，与对照组比较差异有统计学意义（P＜0．01）。结论痛泻宁颗粒联合美沙拉秦颗粒口服治疗轻度、中度UC较单用美沙拉秦颗粒口服能更好地改善患者的临床症状，具有更好的临床疗效。

Experimental study on the treatment of ulcerative colitis with the combination of Tongxiening granule and Mesalazine

Objective To observe the clinical effect of combination of Tongxiening granule and Mesalazine on treating mild and moderate ulcerative colitis(UC) .Methods Totally 380 patients with mild‐to‐moderate UC diagnosed through endoscopy were allocated to the control group (n=190) and observation group(n=190) .For the observation group ,patients were remedied with the combination of Tongxiening Granules and the Mesalazine by oral administration for eight weeks ,meanwhile the control group only received the Mesalazine for eight weeks .The total effective rate of the two groups were statistically analyzed ,and the levels of ser‐um MMP‐2 and MMP‐9 before and after treatment in the two groups were measured .The expression of S100A12 and RAGE were detected by immunohistochemistry SP method .Results The total effective rate of the observation group and the control group was 94 .74% and 89 .47% respectively ,and the difference was statistically significant(P<0 .01) .After treatment ,the expression levels of MMP‐2 and MMP‐9 in the two groups were decreased ,additionally the expression levels in the observation group was lower than those in the control group ,and the difference was statistically significant (P< 0 .01) .After treatment ,the expression levels of RAGE and S100A12 in the observation group were decreased ,and there was a significant difference when compared with the control group(P<0 .01) .Conclusion Combined application of Tongxiening Granules and Mesalazine in treating patients with mild‐to‐mod‐erate UC could better improve clinical symptoms and bring better therapeutic effect than single use of Mesalazine .