| 肠道微生物与脑-肠轴交互作用的研究进展 |
| |
| 引用本文： | 田祖宏,聂勇战. 肠道微生物与脑-肠轴交互作用的研究进展[J]. 传染病信息, 2016, 0(5): 302-307. DOI: 10.3969/j.issn.1007-8134.2016.05.012 |
| |
| 作者姓名： | 田祖宏 聂勇战 |
| |
| 作者单位： | 710043 西安，第四军医大学西京消化病医院肿瘤生物学国家重点实验室，消化内科 |
| |
| 基金项目： | 国家自然科学基金青年基金项目(8140111574) |
| |
| 摘 要： | 肠道微生物在脑-肠轴调节中发挥关键作用,会对宿主的应激反应、焦虑、抑郁和认知功能产生重要影响。肠道菌群失调则可能引发包括多发性硬化症、帕金森病和自闭症等多种中枢神经系统疾病。本文对近十年间肠道微生物参与中枢神经系统疾病相关研究的文献进行汇总,深入剖析微生物-胃肠-脑轴双向调节机制,概括影响微生态稳定的制约因素与调控策略,为微生态疗法在神经系统疾病临床诊疗中的应用提供新思路。
|
| 关 键 词： | 肠道微生物 微生物-胃肠-脑轴 疾病 |
Research progress of the interaction between gut microbes and brain gut axis |
| |
| TIAN Zu-hong,NIE Yong-zhan. Research progress of the interaction between gut microbes and brain gut axis[J]. Infectious Disease Information, 2016, 0(5): 302-307. DOI: 10.3969/j.issn.1007-8134.2016.05.012 |
| |
| Authors: | TIAN Zu-hong NIE Yong-zhan |
| |
| Abstract: | Intestinal microbes play a key role in the regulation of brain gut axis, and have an important influence on the stress response, anxiety, depression and cognitive function of the host. Intestinal flora imbalance may lead to multiple central nervous system diseases, including multiple sclerosis, Parkinson's disease, autism, etc. In this review, the anthors collect past ten-year researches of intestinal microbial involved in central nervous system diseases, make an in-depth analysis of the two-way regulation mechanism of microbiome-gut-brain axis, summarize restricting factors and regulation strategies of micro ecological stability, and provide a new idea for the application of micro ecological therapy in clinical diagnosis and treatment of nervous system diseases. |
| |
| Keywords: | gut microbiota microbiome-gut-brain axis disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
