Acetylcholine and ATP hyperpolarize endothelium via activation of different types of Ca(2+)-activated K+ channels期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Acetylcholine and ATP hyperpolarize endothelium via activation of different types of Ca(2+)-activated K+ channels

Authors:	Marchenko S M

Affiliation:	(1) A. A. Bogomolets Institute of Physiology, National Academy of Science of Ukraine, Kiev

Abstract:	Experiments on rat thoracic aorta showed that ATP and acetylcholine hyperpolarize endothelial cell via selective activation of low (SK) and intermediate (IR) conductance Ca²⁺-activated K⁺ channels, respectively. It was hypothesized that ATP- and acetylcholine-activated Ca²⁺-signals are spatially separated and generated in plasma membrane regions with predominant localization of SK- and IR-channels, respectively.

Keywords:	endothelial cells membrane potential Ca²⁺-activated K⁺-channels acetylcholine ATP
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