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| 从药物不良事件报告看头孢曲松的不合理使用 | |
| 引用本文： | 徐厚明,王越,孙骏,刘乃丰. 从药物不良事件报告看头孢曲松的不合理使用[J]. 中国新药与临床杂志, 2008, 27(9) |
| 作者姓名： | 徐厚明 王越 孙骏 刘乃丰 |
| 作者单位： | 1. 中国药科大学,江苏南京,210009;江苏省药品不良反应监测中心,江苏南京210002 2. 江苏省药品不良反应监测中心,江苏南京,210002 3. 东南大学附属中大医院,江苏,南京210009 |
| 摘 要： | 目的通过分析头孢曲松的相关不良事件,以期为临床合理使用提供理论参考,减少头孢曲松药物不良反应和药源性疾病的发生。方法采用回顾性研究的方法,对江苏省2006年上报的头孢曲松相关不良事件进行分析。结果头孢曲松的不良事件发生比例较高,尤其是10岁以下年龄段病人。38例超出适应证用药。84例使用剂量不合理,其中成人用药剂量过低9例、超剂量29例;12岁以下儿童用药剂量不合理46例。因配伍禁忌使用不当的有6例。孕妇和哺乳期妇女中有25例用药剂量不当,老年病人中共有7例用药剂量不当,肝、肾功能不全病人中有2例用药剂量不当。结论临床使用头孢曲松时应严格掌握其用药适应证和用药剂量,注意配伍禁忌和特殊人群用药,以提高临床疾病治愈率,减少不良事件的发生。 |
| 关 键 词： | 头孢曲松 抗菌药 安全 药品不良事件 |
Study on unreasonable application of ceftriaxone from adverse drug events reports |
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| XU Hou-ming,WANG Yue,SUN Jun,LIU Nai-feng. Study on unreasonable application of ceftriaxone from adverse drug events reports[J]. Chinese Journal of New Drugs and Clinical Remedies, 2008, 27(9) | |
| Authors: | XU Hou-ming WANG Yue SUN Jun LIU Nai-feng |
| Affiliation: | XU Hou-ming~(1,2) WANG Yue~2 SUN Jun~2 LIU Nai-feng~3 (1.China Pharmaceutical University,Nanjing JIANGSU 210009,China,2. Adverse Drug Reaction Monitoring Center of Jiangsu,Nanjing JIANGSU 210002,3. Zhongda Hospital Affiliated to Southeast University,China) |
| Abstract: | AIM To provide a theoretical reference for the clinical application of ceftriaxone in order to reduce adverse drug reactions and drug-induced diseases by analyzing the correlative adverse drug events (ADE) of ceftriaxone.METHODS ADE of ceftriaxone occurred in Jiangsu Province during 2006 were analysed in the method of retrospective study.RESULTS ADE of ceftriaxone occurred in rather high proportion especially in patients below the age of 10.The complicated outcomes showed 38 patients with surpassing drug ap... |
| Keywords: | ceftriaxone anti-bactirial agents safety adverse drug events |
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