红细胞体积分布宽度与糖代谢异常/糖耐量异常和糖尿病相关

目的探讨红细胞体积分布宽度（RDW）与2型糖尿病（T2DM）、空腹血糖受损／葡萄糖耐量异常（IFG／IGT）的相互关系。方法对152例在我院定期进行健康体检或治疗的患者，依据血糖情况分为3组，其中T2DM组42例，IFG／IGT组38例，正常对照（NGT）组72例，采取空腹血，采用全自动血液分析仪测定RDW、血红蛋白，多功能血生化自动分析仪测定血总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血肌酐、血尿素氮和空腹血糖，同时统计高血压、冠心病的发病率并分析其关系。结果RDW在T2DM组、IFG／IGT组和NGT组之间比较具有统计学差异，其中T2DM组和NGT组、IFG／IGT组比较，差异均有统计学意义（P〈0．05或P〈0．01），IFG／IGT组与NGT组比较差异无统计学意义（P〉0．05）。多因素直线回归分析显示空腹血糖（P〈0．01）和高密度脂蛋白胆固醇（P〈0．05）是RDW的独立危险因子。结论T2DM患者RDW升高，RDW的变化与空腹血糖水平相关。

Red blood cell distribution width is closely associated with impaired fasting glucose/impaired glucose tolerance and diabetes mellitus

Objective To investigate the association of red blood cell distribution width （RDW） with diabetes, impaired fasting glucose （IFG） and impaired glucose tolerance （IGT）. Methods Seventy-two cases of normal glucose tolerance（NGT）, 38 cases of IFG/IGT and 42 case of diabetes mellitus were enrolled in this study. RDW was determind using a coulter together with hemoglobin. Total plasma cholesterol, plasma triglyceride, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, plasma creatinine concentration, blood urea nitrogen and fasting glucose were determined using a multichannel analyzer, and meanwhile the incidence of hypertension, coronary heart disease were counted. Results The level of RDW showed significant differences between NGT, IFG/IGT and diabetes mellitus group（ P〈0. 01 ）. The level of RDW of diabetes mellitus group （ 13.55± 1.05 ） was significantly higher than that in the other two groups （ NGT group, 12. 76±0. 94, P〈0. 01 ; IFG/IGT group, 13.12±0.67, P〈0. 05）. Fasting glucose （ β=0. 262, P〈0. 01 ） and HDL-C （ β =-0. 215, P〈0. 05） were independent risk factors for RDW. Conclusions The patients with diabetes mellitus are more likely to present with high level of RDW, and fasting glucose is associated with RDW.