2型糖尿病合并脑梗死患者糖化血红蛋白、血清同型半胱氨酸与颈动脉内膜中层厚度分析

目的探讨老年2型糖尿病合并脑梗死患者糖化血红蛋白（HbA1c）,血清同型半胱氨酸（Hcy）水平与颈动脉内膜中层厚度（IMT）的关系。方法对49例老年2型糖尿病脑梗死患者、40例老年2型糖尿病无脑梗死患者、43例健康老年人（对照组）进行HbA1c,血清Hcy与IMT的相关性分析。结果老年2型糖尿病合并脑梗死组的HbA1c、血清Hcy、IMT水平明显高于老年2型糖尿病无脑梗死组和对照组（P〈0.05）,2型糖尿病合并脑梗死组中的IMT与HbA1c、血清Hcy、总胆固醇呈正相关（P〈0.05）。结论老年2型糖尿病患者除严格控制血糖外,有必要检测HbA1c、血清Hcy与IMT,以早期预防或延缓大血管并发症的出现,从而降低脑梗死的患病率和病死率。

Clinical significance of glycosylated hemoglobin,serum homocysteine levels and internal carotid artery intimamedia thickness in the elderly patients with cerebral infarction complicated with type 2 diabetes mellitus

Objective To investigate the association of glycosylated hemoglobin （ HbAlc）, serum level of homocysteine （Hcy） with internal carotid artery intima thickness （IMT） in the elderly patients with type 2 diabetes mellitus （T2DM） and cerebral infarction. Methods Forty-nine elderly patients with T2DM complicated with cerebral infarction, 40 elderly patients with T2DM without cerebral infarction and 43 cases of healthy elderly people （ control group） were en- rolled in this study. The levels of HbAlc, serum Hcy and IMT were detected and analyzed. Results The levels of HbAlc, serum Hcy and IMT in the elderly patients with T2DM complicated with cerebral infarction were obviously higher than those in the elderly patients with T2DM without cerebral infarction and the control group （P〈 0. 05）. In T2DM complicated with cerebral infarction group, HbAlc, serum Hcy and total cholesterol were positively correlated with IMT （P〈 0. 05）. Conclusions For the elderly patients with T2DM, it is important to detect the levels of HbAlc, serum Hcy and IMT, which help to find or prevent from major vascular complications.