In Vitro Genotoxic and Cytotoxic Effects of Protein Somatic Products from Helminths on Donor Blood Lymphocytes |
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| Authors: | Vl. Ya. Bekish A. D. Durnev |
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| Affiliation: | Department of Medical Biology and General Genetics, Vitebsk State Medical University, Moscow. bekishvl@tut.by |
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| Abstract: | ![]()
Protein somatic products of adult helminths Hymenolepis nana and Toxocara canis and secretory-excretory somatic product of Trichinella spiralis larvae in vitro produced genotoxic and cytotoxic effects on donor blood lymphocytes, which manifested in accumulation of single-chain breaks, alkaline-labile sites in nuclear DNA, and apoptotic cells. This effect depended on the concentration of parasitic protein products during coculturing. |
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| Keywords: | helminths alkaline single cell gel electrophoresis donor lymphocytes genotoxicity cytotoxicity |
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