| Y染色体微缺失与男性无精少精的相关关系 |
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| 引用本文： | 叶长烂,江悦华,王捷,张中芬,吴小丽,郑霖. Y染色体微缺失与男性无精少精的相关关系[J]. 中国实验诊断学, 2010, 14(4): 566-568 |
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| 作者姓名： | 叶长烂 江悦华 王捷 张中芬 吴小丽 郑霖 |
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| 作者单位： | 广州军区广州总医院医学,实验科,广州,510010 |
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| 摘 要： | 目的探讨Y染色体微缺失与男性无精少精的相关关系和临床意义。方法利用15个Y染色体特异序列标签位点,以多重PCR法对广州军区总医院2006年1月-2008年1月门诊的151例男性不育患者(25例无精症、126例少精症)进行Y染色体微缺失(AZF)检测。对照组为40例已正常生育的男性。结果151例男性不育患者中,AZF缺失8例,总缺失率为5.3%,其中25例无精症不育患者中,AZF缺失3例,缺失率为12%;126例少精症不育患者中,AZF缺失5例,缺失率为4.0%。AZFc和AZFd为缺失热区。对照组40例正常男性均未发现Y染色体微缺失。结论AZF缺失是男性不育症的重要原因之一,对临床上无精症、少精症患者应进行Y染色体微缺失检测。
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| 关 键 词： | Y染色体微缺失 无精症 少精症 |
The correlation of Y chromosome microdeletion with Azoospermia and Oligozoospermia |
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| YE Zhang-lan,JIANG Yue-hua,Wang Jie,et al.. The correlation of Y chromosome microdeletion with Azoospermia and Oligozoospermia[J]. Chinese Journal of Laboratory Diagnosis, 2010, 14(4): 566-568 |
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| Authors: | YE Zhang-lan JIANG Yue-hua Wang Jie et al. |
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| Affiliation: | YE Zhang-lan,JIANG Yue-hua,Wang Jie,et al.(Department of Medical Research,Guangzhou General Hospital of Guangzhou Comm,,Guangzhou 510010,China) |
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| Abstract: | Objective To determine the relevant relationship and clinical significance of Y chromosome microdeletion with Azoospermia and Oligozoospermia.Methods Y chromosome microdeletions were detected from 151 patients(25 patients with azoospermia and 126 patients with oligozoospermia) and 40 normal fertile men by multiple polymerase chain reations with 15 Y chromosome specific sequence-tagged site.Results Of all the 151 male infertility patients,8 cases of AZF microdeletion were found with an overall prevalence of ... |
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| Keywords: | Y chromosome microdeletion Azoospermia Oligozoospermia |
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