Dibutyryl-cAMP induces SNAP-25 translocation into the neurites in PC12. |
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| Authors: | P P Sanna F E Bloom M C Wilson |
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| Institution: | Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, CA 92037. |
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| Abstract: | SNAP-25 immunoreactivity was translocated into the endings of the processes induced in PC12 cells by dibutyryl-cAMP-treatment. Conversely, the protein was not present in the endings of the processes seen after NGF-treatment unless dibutyryl-cAMP was used simultaneously. This redistribution of SNAP-25 immunoreactivity appeared to be dependent upon new protein synthesis. Finally, dibutyryl-cAMP was capable of inducing SNAP-25 expression. |
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