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Amino acid transport by synaptosomes isolated from post mortem human brain |
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| Authors: | J. A. Hardy D. E. Bateman A. M. Kidd J. A. Edwardson G. B. Singh P. R. Dodd |
| Affiliation: | (1) Present address: Department of Pathology, University of Umeå, Umeå, Sweden;(2) MRC Neuroendocrinology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK;(3) Department of Pathology, Hexham General Hospital, Northumberland, UK;(4) Department of Pharmacology, University of Sydney, New South Wales, Australia |
| Abstract: | Summary Synaptosomes isolated from post mortem human brain release the transmitter amino acids upon depolarisation. Active preparations can be isolated for up to 24 hours post mortem. The amount of depolarisationinduced release of the transmitter amino acids is correlated with the rate of oxygen uptake. Only when this correlation is taken into consideration would it be possible to detect disease-related changes in presynaptic aminoacid transport systems. |
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