LRP16在肝硬化组织、癌旁组织及癌组织中的表达及意义

目的:探讨白血病相关蛋白16(LRP16)在肝癌中的表达规律,寻求其作为肝癌早期诊断及判断临床预后指标的可能性。方法:用Western印迹杂交法检测42例肝癌标本或新鲜组织中LRP16的表达情况,分析其与病理因素的关系。结果:LRP16在肝硬化组织、癌旁组织及癌组织中均有表达,但表达量依次减少。LRP16高表达者一般肿瘤直径较小,具有完整的包膜,一般无血管侵犯,多为中低分化腺癌。结论:LRP16高表达者具有较好的生物学特性。LRP16可能在判断肝癌生物学特性方面具有一定前景。

Expression and significance of LRP16 gene in liver cancer

Objective:To probe the protein level and the clinical pathological significance of LRP16 gene in the patients of liver cancer.Methods: Collect fresh resective tissues and the clinical data of patients with hepatocellular carcinoma,detecting the protein level of LRP16 in carcinoma tissues and the matched paratumor normal tissues by using Western blot method,and then analyze the relevance between LRP16 and clinical pathological feature.Results:According to the results of Western blot,compared with that in peritumor and normal tissues,LRP16 was lower-expressed in carcinoma tissues.Significant associations were found between LRP16 and the number of nodules,tumor size,Edmonson-Steiner class and ect.Conclusion: LRP16 was lowered-expressed in carcinoma tissues,compared with that in peritumor and normal tissues.LRP16 overexpression is closely correlated to lessermalignant biological behavior and LRP16 status are good prognostic factors.