肺炎支原体诱导儿童哮喘的免疫学观察

目的:探讨肺炎支原体(MP)感染诱发儿童哮喘的临床免疫学特点,以阐明肺炎支原体感染与支气管哮喘发病机制间的密切联系。方法:将90例患儿的临床资料分为3组进行比较,MP伴哮喘组30例,单纯MP不伴哮喘组30例,支气管哮喘组30例。检测每组的外周血WBC及分类,胸片,痰中嗜酸性细胞计数,血清IgE定量。结果:全部病例WBC总数无显著性差异,MP伴哮喘组和支气管哮喘组在外周血和痰嗜酸性细胞计数、IgE等方面高于单纯MP不伴哮喘组(P<0.05)。结论:MP感染可以诱导患儿哮喘,发病机理与免疫机制紊乱有关,抗感染治疗MP的同时可应用支气管扩张剂。

THE IMMUNOLOGIC OBSERVATION OF MYCOPLASMA-INDUCED ASTHMA IN CHILDREN

Objective: To investigate the immunologic features of mycoplasma(MP) induced asthma in children,and clarify the relationship between MP infection and the pathogenesis of bronchial asthma. Methods: Ninety cases of children patients were divided into 3 groups (n=30): MP-induced asthma group, only MP (non-asthma) group and simple asthma group. WBC count and classification,lung X-ray,acidophil sorting in sputum and serum IgE were tested for all of the patients. Results:It did not show any statistic differentiation in WBC number in all the cases. MP-induced asthma or simple asthma group had more acidophil in blood or sputum,and higher lever of IgE than that of MP (non-asthma) group (P < 0.05). Conclusions: The infection of MP may induce asthma of children, and its mechanism is relation to immunological disorder. The anti-MP withbronchial dilation is effective in the treatment of MP induced-asthma.