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| 大剂量免疫抑制剂治疗自身免疫性疾病初探(附4例病例分析) | |
| 引用本文： | 艾脉兴,冷晓梅,曾小峰. 大剂量免疫抑制剂治疗自身免疫性疾病初探(附4例病例分析)[J]. 中日友好医院学报, 2006, 20(5): 278-280 |
| 作者姓名： | 艾脉兴 冷晓梅 曾小峰 |
| 作者单位： | 1. 中日友好医院,风湿免疫科,北京,100029 2. 中国医学科学院,中国协和医科大学,北京协和医院,风湿免疫科,北京,100730 |
| 摘 要： | 目的：探讨大剂量化疗治疗自身免疫性疾病的可行性、疗效以及安全性.方法：分析误用大剂量免疫抑 制剂的4例自身免疫性疾病（系统性红斑狼疮2例、类风湿关节炎2例）患者的临床特点及转归,并复习有关文献.结果：4例患者误用大剂量免疫抑制剂并经相关治疗后病情均获得长期缓解,实验室指标显示病情均明显改善.结论：密切监测下的大剂量化疗治疗自身免疫性疾病安全可行,有望使疾病获得长期缓解. |
| 关 键 词： | 自身免疫性疾病 大剂量化疗 治疗 |
| 文章编号： | 1001-0025(2006)05-0278-03 |
| 收稿时间： | 2006-06-05 |
| 修稿时间： | 2006-07-25 |
High-dose immunosuppressive therapy without stem cell rescue for autoimmune disease with 4 case reports |
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| AI Mai-xing,LENG Xiao-mei,ZENG Xiao-feng. High-dose immunosuppressive therapy without stem cell rescue for autoimmune disease with 4 case reports[J]. Journal of China-Japan Friendship Hospital, 2006, 20(5): 278-280 | |
| Authors: | AI Mai-xing LENG Xiao-mei ZENG Xiao-feng |
| Affiliation: | Department of Rheumatology,China-Japan Friendship Hospital,Beijing, 100029,China |
| Abstract: | Objective:To explore the feasibility,efficacy,and safety of high-dose immunosuppressive therapy in patients with autoimmune diseases.Methods:Four patients(2 patients with systemic lupus erythematosus and another 2 patients with rheumatoid Arthritis),who misused high-dose chemotherapy,were reported.The features of clinical manifestation,outcome and lab findings were studies.The literatures associated with high-dose chemotherapy without stem cell rescue for autoimmune disease were reviewed.Results:All patients showed remission after high-dose chemotherapy with support therapy.The lab findings associated with disease manifestation were nearly normal.Conclusion:Under intense care,high-dose chemotherapy might be feasible and safe,and could induce complete remission in patients with refractory,severe autoimmune disease. |
| Keywords: | autoimmune disease high-dose chemotherapy treatment |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |