| 橐吾属植物中肝毒吡咯里西啶生物碱的LC/MSn检测 |
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| 引用本文： | 濮社班,徐德然,张勉,周红华,王峥涛,余国奠. 橐吾属植物中肝毒吡咯里西啶生物碱的LC/MSn检测[J]. 药学学报, 2004, 39(10): 831-835 |
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| 作者姓名： | 濮社班 徐德然 张勉 周红华 王峥涛 余国奠 |
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| 作者单位： | 1. 中国药科大学中药学院,江苏,南京,210038
2. 中国药科大学分析测试中心,江苏,南京,210038 |
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| 基金项目： | 国家自然科学基金委员会(NSFC)，国家杰出青年基金项目(39825129). |
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| 摘 要： | 目的橐吾属植物中微量成分肝毒吡咯里西啶生物碱(HPA)的检测。方法采用薄层色谱法(TLC)、液相色谱与多级质谱联用法(LC/MSn)。结果对橐吾属22种植物进行了HPA的LC/MSn法检测，其中18种橐吾属植物中检测到了HPA。结论利用LC/MSn法首次检测到东俄洛橐吾等15种橐吾属植物含有不同类型和种类的HPA，应进一步进行提取、分离与鉴定，并研究其毒性与活性；对不同种类、不同来源的橐吾属植物材料应分别检测其HPA。
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| 关 键 词： | 橐吾属 肝毒吡咯里西啶生物碱 液相色谱-多级质谱联用法 |
| 收稿时间： | 2004-01-12 |
Detection of hepatotoxic pyrrolizidine alkaloids in Ligularia Cass. with LC/MSn |
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| PU She-ban,XU De-ran,ZHANG Mian,ZHOU Hong-hua,WANG Zheng-tao,YU Guo-dian. Detection of hepatotoxic pyrrolizidine alkaloids in Ligularia Cass. with LC/MSn[J]. Acta pharmaceutica Sinica, 2004, 39(10): 831-835 |
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| Authors: | PU She-ban XU De-ran ZHANG Mian ZHOU Hong-hua WANG Zheng-tao YU Guo-dian |
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| Affiliation: | College of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210038, China. |
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| Abstract: | Aim To detect the hepatotoxic pyrrolizidine alkaloids ( HPA ) in the genus Ligularia Cass. . Methods The alkaloid extracts of Ligularia plant materials were detected and analyzed by the method of combination of TLC, and LC/MSn. Results Among 22 species of Ligularia Cass. , HPA were detected in 18 species with LC/MSn, and no HPA was detected in the remaining 4 species. Conclusion HPA was first detected with LC/MSn in L. tongelensis and other 15 species of Ligularia Cass. ; HPA from these plants should be isolated, separated and identified and it is necessary to study the activities and toxicities of the HPA. The types and kinds of HPA from different species and sources are different, they should be detected separately. |
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| Keywords: | Ligularia Cass. hepatotoxic pyrrolizidine alkaloids LC/MSn |
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