Pentoxifylline attenuates edema formation in proteolytic enzyme-induced lung injury |
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| Authors: | B A Rosenfeld T J Toung M J Sendak M J Breslow G M Hutchins R J Traystman |
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| Institution: | Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD. |
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| Abstract: | Ex vivo canine lung lobes were exposed to a pancreatic proteolytic enzyme (chymotrypsin) alone or chymotrypsin after pretreatment with a continuous infusion with pentoxifylline. The lobes exposed to chymotrypsin gained 133 g, while the pentoxifylline-treated lobes gained only 65 g (p less than .05) over the 3-h experimental period. These results suggest that pentoxifylline significantly attenuates the lung weight gain associated with chymotrypsin. |
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