核糖体生物合成与肿瘤的研究进展

核糖体生物合成是细胞内重要的生物学过程,决定了细胞内蛋白质合成的速率。在肿瘤细胞旺盛的生长压力下,肿瘤中核糖体生物合成发生异常调控。有越来越多的研究表明核糖体生物合成的异常可能会促进肿瘤的发生发展,并且它也逐渐被认为是多种肿瘤的一个可行的治疗靶点。本文简要综述了核糖体生物合成过程及其在肿瘤中的异常和调控,以及药物靶向核糖体生物合成治疗肿瘤的研究进展。

Research Progress of Ribosome Biogenesis and Cancer

As an important biological process, ribosome biogenesis determines the rate of protein synthesis in cells. However, ribosome biogenesis is abnormally regulated in tumors under strong growth pressure. More and more evidences have shown that abnormal ribosome biogenesis might promote tumorigenesis and malignant transformation. It is gradually considered as a feasible therapeutic target for many types of tumors. This article briefly reviews the process of ribosome biogenesis, its abnormality and regulation in tumor, and drug targeting ribosome biogenesis in tumor treatment.