癌性疼痛患者营养状况与血清C反应蛋白的相关性

目的研究癌性疼痛患者营养状况、炎性反应水平及各项指标间的相关性。方法选取146例癌痛患者为研究对象,采用NRS、NRS-2002、PG-SGA、人体测量、血液学检查等方法进行疼痛评估、营养风险筛查和营养状况评估,研究不同疼痛程度患者营养状态、炎性反应水平等各项指标的差异及相关性。结果两组不同NRS评分患者NRS-2002、PG-SGA、胆碱酯酶差异均有统计学意义(均P<0.05)。两组不同C反应蛋白浓度患者的前白蛋白、白蛋白、血红蛋白、胆碱酯酶、白细胞、中性粒细胞比例、淋巴细胞总数差异有统计学意义(P<0.05)。相关性分析提示:NRS与胆碱酯酶、淋巴细胞总数和BMI呈负相关(P=0.000,P=0.003,P=0.000),与NRS-2002、PG-SGA呈正相关(P=0.003,P=0.000)。C反应蛋白浓度与前白蛋白、白蛋白、胆碱酯酶、血红蛋白、淋巴细胞总数呈负相关(P=0.000,P=0.000,P=0.000,P=0.002,P=0.004),与NRS-2002、PG-SGA呈正相关(P=0.020,P=0.028)。结论癌性疼痛患者的营养风险和营养不良发生率都较高,具有较高血清C反应蛋白浓度的癌性疼痛患者的营养状况更差。

Correlation Between Nutritional Status and Serum C-reactive Protein in Patients with Cancer Pain

Objective To investigate the nutritional status, inflammation level and the correlation among various indicators in patients with cancer pain. Methods A total of 146 patients with cancer pain were enrolled. NRS, NRS-2002, PG-SGA, anthropometric, dietary assessment, hematology and other methods were used for pain assessment, nutrition risk screening and nutritional status assessment, and to analyze the differences and correlation among various nutritional indicators in different degree of pain. Results There were significant differences in NRS-2002, PG-SGA and CHE between the two groups of different NRS scores (P<0.05). There were significant differences in theprealbumin (PA), albumin (ALB), hemoglobin(HGB), cholinesterase (CHE), white blood cell (WBC), neutrophil ratio (N%) and lymphocyte (LYM) between the two groups of different C-reactive protein (CRP) concentrations (P<0.05). NRS was negatively correlated with total number of CHE, LYM and BMI (P=0.000, P=0.003, P=0.000), and positively correlated with NRS-2002 and PG-SGA (P=0.003, P=0.000). The concentration of CRP was negatively correlated with the total number of PA, ALB, CHE, HGB and LYM (P=0.000, P=0.000, P=0.000, P=0.002, P=0.004), and positively correlated with NRS-2002 and PG-SGA (P=0.020, P=0.028). Conclusion The nutritional risk and malnutrition incidence are high in patients with cancer pain. The cancer patients with higher serum C-reactive protein concentration have worse nutritional status.