| 玫瑰孢链霉菌基因组挖掘研究进展 |
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| 引用本文： | 叶磊鑫,胡昌华,廖国建.玫瑰孢链霉菌基因组挖掘研究进展[J].中国抗生素杂志,2020,45(5):411-417. |
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| 作者姓名： | 叶磊鑫 胡昌华 廖国建 |
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| 摘 要： | 玫瑰孢链霉菌是重要抗生素达托霉素的产生菌。基因组挖掘发现该菌具有丰富的次级代谢产物合成潜力，激活沉默次级代谢产物生物合成基因簇，发现了10多种具有多种生物活性的次级代谢产物。本文回顾了玫瑰孢链霉菌次级代谢产物的研究进展，以及激活这些沉默生物合成基因簇的研究策略。这些研究为其他链霉菌基因组挖掘提供了有效的思路和方法学参考。
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| 关 键 词： | 基因组挖掘 玫瑰孢链霉菌 沉默基因簇 肽基因组学 |
Genome mining of Streptomyces roseosporus |
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| Ye Lei-xin,Hu Chang-hua,Liao Guo-jian.Genome mining of Streptomyces roseosporus[J].Chinese Journal of Antibiotics,2020,45(5):411-417. |
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| Authors: | Ye Lei-xin Hu Chang-hua Liao Guo-jian |
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| Abstract: | Streptomyces roseosporus is an important industrial producer of the first line antibiotic daptomycin. Genome mining has revealed a large cryptic secondary metabolism gene clusters. Several activation strategies have been applied to this strain and allowed the identification of over 10 secondary metabolites. This paper focuses on recent advances in the strategies for activating cryptic gene cluster in S. roseosporus by genomics methods. |
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| Keywords: | Genome mining Streptomyces roseosporus Silent gene cluster Peptidogenomics |
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