血清骨桥蛋白在高血压性基底节区出血发病90 d预后评估中的价值

目的 探讨血清骨桥蛋白（OPN）在高血压性基底节区出血病人发病90 d预后评估中的价值。方法 选取2016年6月至2019年1月收治的高血压性基底节区出血160例和健康体检者100例（对照组），采用酶联免疫吸附试验检测血清OPN水平。发病90 d，用改良Rankin量表评分评估预后，0~2分为预后良好，3~5分预后不良。结果 160例中，预后不良78例，预后良好82例。脑出血病人血清OPN浓度（7.98±0.12）ng/ml]明显高于对照组（5.23±0.13）ng/ml；P<0.01]。多因素logistic回归分析显示，血清OPN水平≥7.58 ng/ml是脑出血发病90 d预后不良的独立危险因素（P<0.05）。ROC曲线分析结果显示，血清OPN水平预测脑出血发病90 d预后的曲线下面积为0.813，95%置信区间为0.743~0.868，当截断值为7.58 ng/ml时，预测不良预后的灵敏度为85.9%，特异度为65.8%。结论 高血压性基底节区出血病人血清OPN明显增高，对发病90 d预后评估有一定价值。

Value of serum osteopontin in predicting 90-day prognoses of patients with acute cerebral hemorrhage

Objective To explore the value of serum osteopontin (OPN) in the prognostic evaluation of patients with hypertensive basal ganglia hemorrhage (HBGH) at 90 days. Methods Serum OPN levels were detected in 160 patients with HBGH and 100 healthy subjects (control group) from June 2016 to January 2019 by enzyme-linked immunosorbent assay. At 90 days, the prognosis was evaluated by the modified Rankin scale (mRS) score, with good prognosis of mRS score 0~2 and poor prognosis of mRS score 3~5. Results Of 160 patients with HBGH, 78 patienst had poor prognoses and 82 had good prognoses. The serum OPN lvele of patients with HBGH (7.98±0.12)ng/ml] was significantly higher than that of the control group (5.23±0.13) ng/ml; P<0.01]. Multivariate logistic regression analysis showed that serum OPN level ≥7.58 ng/ml was an independent risk factor for poor prognoses of patients with HBGH at 90 days (P<0.05). ROC curve analysis showed that the area under the curve for serum OPN level ≥7.58 ng/ml to predict the poor prognoses of patients with HBGH at 90 days was 0.813 (95% CI 0.743~0.868), and the sensitivity and specificity were 85.9% and 65.8%, respectively. Conclusion The serum OPN of patients with HBGH is significantly increased, which has a certain value for the prognosis evaluation at 90 days.