妊娠期糖尿病孕妇血清CTRP6水平及意义

目的 研究妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇血清C1q/肿瘤坏死因子相关蛋白6(C1q/tumor necrosis factor-related protein 6,CTRP6)水平及其与胰岛素抵抗和炎性细胞因子水平的关系,探讨CTRP6在GDM中的作用。 方法 选择衢州市妇幼保健院2019年1—12月住院分娩的GDM患者86例作为B组,同期住院分娩的正常孕妇86例作为A组。测定空腹血糖(fasting blood glucose,FPG)、糖化血红蛋白(glycated hemoglobin,HbA1C)、空腹胰岛素(fasting insulin,FINS)和高敏-C反应蛋白(high-sensitivity-C reactive protein,hs-CRP)水平。计算胰岛-β细胞功能指数(islet-βcell function index,HOMA-β)和胰岛素抵抗指数(Insulin resistance index,HOMA-IR)。采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)测定血清CTRP6和白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平。 结果 B组血清CTRP6水平和FPG、HbA1C水平高于A组(均P<0.05)。B组FINS和HOMA-IR高于A组(均P<0.05),HOMA-β低于A组(P<0.05)。B组血清hs-CRP、IL-6、TNF-α水平均高于A组(均P<0.05)。GDM患者血清CTRP6水平与FPG、HbA1C、FINS、HOMA-IR、hs-CRP、IL-6、TNF-α水平均呈正相关(均P<0.05),与HOMA-β呈负相关(P<0.05)。 结论 GDM患者血清CTRP6水平升高,其水平与胰岛素抵抗和血清炎性细胞因子水平关系密切。 

Serum CTRP6 level in pregnant women with diabetes during pregnancy and its significance

Objective To study the serum C1 q/tumor necrosis factor-related protein 6(CTRP6) level in pregnant women with gestational diabetes mellitus(GDM) and its relationship with insulin resistance and inflammatory cytokine levels, and to explore the role of CTRP6 in GDM. Methods A total of 86 patients with GDM who were hospitalized and delivered in Quzhou Maternal and Child Health Hospital from January 2019 to December 2019 were selected as group B, and 86 normal pregnant women who were hospitalized and delivered during the same period were selected as group A. The fasting blood glucose(FPG), glycated hemoglobin(HbA1 C), fasting insulin(FINS) and high-sensitivity-C reactive protein(hs-CRP) levels were measured. The islet-β cell function index(HOMA-β) and insulin resistance index(HOMA-IR) were calculated. The levels of serum CTRP6, interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were measured by enzyme-linked immunosorbent assay(ELISA). Results The serum CTRP6, FPG and HbA1 C levels in group B were higher than those in group A(all P<0.05). FINS and HOMA-IR in group B were higher than those in group A(all P<0.05), and HOMA-β was lower than that of group A(P<0.05). The levels of serum hs-CRP and TNF-α in group B were higher than those in group A(all P<0.05). The serum CTRP6 level was positively correlated with FPG, HbA1 C, FINS, HOMA-IR, hs-CRP, IL-6 and TNF-α levels(all P<0.05), and was negatively correlated with HOMA-β(P<0.05). Conclusion The serum CTRP6 level in GDM patients is elevated, and its level is closely related to insulin resistance and serum inflammatory cytokine levels.