3种质子泵抑制剂治疗消化性溃疡疗效观察

目的观察奥美拉唑、兰索拉唑、泮托拉唑在治疗消化道溃疡的临床疗效。方法将消化道溃疡患者135例随即分为3组,A组(44例)给予奥美拉唑治疗,B组(44例)给予兰索拉唑治疗,C组(47例)给予泮托拉唑治疗,给药途径均为口服。观察3组临床疗效和不良反应。结果 3组临床疗效和不良反应比较差异均无统计学意义(P>0.05)。结论 3种质子泵抑制剂对消化道溃疡患者的作用都很显著,但泮托拉唑不良反应最少、安全性更高,且对其他合用药物影响小,值得临床推广应用。

Clinical observations of 3 kinds of proton pump inhibitors in the treatment of peptic ulcer

Objective To observe the clinical observation of omeprazole, lansoprazole,pantoprazole in the treatment of peptic ulcer. Methods 135 cases of patients with peptic ulcer were randomly divided into three groups. Group A（44 cases） was treated with omeprazole, Group B （44 cases ） was given with lansoprazole, Group C （47 cases ） was treated with panto- prazole. Observed the efficacy and adverse reactions of three groups. Results The clinical efficacy and adverse reactions of three groups was no significant difference（P 〉 0.05）. Conclusion All of the three germplasm proton pump inhibitors have a significant efficacy. Pantoprazole has the least adverse reactions, more secure, and the least impact on other combination drugs, should be widely applied.