复方倍他米松联合透明质酸钠治疗膝骨关节炎45例体会

目的观察关节腔内注射复方倍他米松与透明质酸钠治疗膝骨性关节炎的效能。方法 45例关节腔积液膝骨性关节炎患者随机分为治疗组(30例)和对照组(15例)。治疗组采用复方倍他米松与透明质酸钠治疗膝骨关节炎,对照组单用透明质酸钠。观察两组临床疗效、VAS评分及不良反应发生情况。结果 2组治疗后1周、2周、4周、3个月的VAS评分均较治疗前明显降低,经比较差异有统计学意义(P<0.05);与对照组比较,治疗组治疗后VAS评分降低的更加明显,经比较差异有统计学意义(P<0.05)。治疗组总有效率达96.8%,明显高于对照组有效率(70%)(P<0.01)。结论对关节腔内有关节液的骨性关节炎联合治疗比单纯用透明质酸钠效果更好。

Treatment experience of compound betamethasone sodium and hyaluronate for 45 patients with knee osteoarthritis

Objective To observe the role of intra-articular injection of compound betamethasone sodium and hyaluronate for patients with knee osteoarthritis.Methods Forty-five patients with joint effusion of knee osteoarthritis were randomized into treatment group(n=30) and control group(n=15).The treatment group received compound betamethasone sodium hyaluronate in the treatment of knee osteoarthritis,and the control group received sodium hyaluronate.The clinical efficacy,VAS scores and adverse events were observed.Results One week,2 weeks,4 weeks and 3 months after treatment,VAS scores was significantly reduced in the two groups(P<0.05). Compared with the control group,VAS score decreased more significantly in the treatment group(P<0.05).In the treatment group,the total effectiveness rate was 96.8%,significantly higher than that in the control group(70%)(P<0.01).Conclusion For the joint cavity section with fluid,the combined therapy of osteoarthritis has better effect than sole use of sodium hyaluronate.