哺乳动物雷帕霉素靶蛋白信号通路在帕金森病中的作用

哺乳动物雷帕霉素靶蛋白（mTOR）是一种保守的丝氨酸/ 苏氨酸蛋白激酶，调控细胞生长、增殖、运动、存活和自噬等生物学活动，作为细胞代谢和生存的关键调节剂，现已成为帕金森病（PD）的新型治疗靶点。越来越多的研究表明，在PD模型中恢复受干扰的mTOR信号转导可以预防神经元的死亡。然而，在PD中通过mTOR介导产生作用的分子机制尚未完全清楚。现将mTOR信号通路与PD关系的最新进展进行综述，并进一步讨论mTOR信号通路在PD中的潜在作用。

Role of mTOR signaling in Parkinson's disease

Mammalian target of rapamycin （mTOR）， as a conserved serine/threonine protein kinase， can regulatebiological activities such as cell growth， proliferation， migration， survival and autophagy. As a key regulator of cellmetabolism and survival， mTOR has now become a new therapeutic target for Parkinson's disease. A growing body ofresearch indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal death. Nevertheless，molecular mechanisms underlying mTOR-mediated effects in Parkinson's disease have not been fully understoodyet. This paper reviewed recent progress in characterizing the association of mTOR signaling with risk factors ofParkinson's disease and further discussed the potential roles of mTOR in Parkinson's disease.