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Intracellular reorganization and ultrastructural stereological analysis of cardiomyocytes of W/SSM rats with genetically determined cardiomyopathy
Authors:E. L. Lushnikova  L. M. Nepomnyashchikh  O. A. Postnikova  V. G. Tsimmerman
Affiliation:(1) Laboratory of Histocytometry and Stereology, Laboratory of General Pathological Anatomy, Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Science, Novosibirsk;(2) Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk
Abstract:
We studied ultrastructure of cardiomyocytes of W/SSM rats with inherited hypertrophic cardiomyopathy bred from Wistar rats by hypersensitivity to cataractogenic action of high galactose doses. The observed dynamics of quantitative and qualitative changes in the main sarcoplasmic organelles reflects general principles of spatial and temporal reorganization of cardiac muscle cells induced by hypertrophy of different genesis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 233–237, August, 1999
Keywords:W/SSM rats    hypertrophic cardiomyopathy    cardiomyocytes    electron microscopy    morphometry    stereology
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