不同种类糖皮质激素对AECOPD临床疗效的比较

目的研究不同种类糖皮质激素对慢性阻塞性肺疾病急性加重期（AECOPD）的临床疗效及差异。方法 170例AECOPD患者随机分为5组,泼尼松龙组口服给予泼尼松龙30～40mg/d,氢化可的松、甲泼尼松龙、地塞米松组分别静脉给予氢化可的松（20mg/d）、甲泼尼松龙（40mg/d）、地塞米松（5mg/d）。连用7d。对照组给予常规治疗。统计并比较治疗过程中症状消失时间、总有效率及不良反应发生率。结果与C-G组相比,各糖皮质激素治疗组总有效率均明显高于C-G组（P〈0.05）,甲泼尼松龙有较高的有效率、较低的不良反应发生率和更短的症状消除时间,其有效率和不良反应发生率分别为91.17%、14.71%。结论糖皮质激素治疗AECOPD宜选择甲泼尼松龙。

Clinical curative effect comparison of different kinds of glucocorticoid treated with AECOPD

Objective To study on clinical curative effect and its differences of different kinds of glucocorticoid treated with AECOPD.Methods 170 patients with AECOPD were randomly divided into 5 groups.Prednisone group was given prednisone（30-40 mg/d） by oral medication.Hydrocortisone,methylprednisolone and dexamethasone groups were injected hydrocortisone（20 mg/d）,methylprednisolone（40 mg/d） and dexamethasone（5 mg/d） by intravenous drip,respectively.Each group was administered for 7 days.Normal therapy was conducted in the control group.The symptoms disappear time,the rate total effective and adverse reactions were counted and compared.Results Compared with the C-G group,the glucocorticoid treatment group total effective rate were significantly higher than that of the C-G group.Methylprednisolone had higher efficient,lower incidence of adverse reactions and shorter eliminate time of symptoms.It’s efficient and incidence of adverse reactions were 91.17% and 14.71%,respectively.Conclusion In the glucocorticoid,methylprednisolone is the most appropriate choice for the treatment of AECOPD.