初治急性白血病应用氟康唑预防真菌感染的临床观察

目的观察氟康唑在初治急性白血病（AL）患者粒细胞缺乏期预防真菌感染的疗效。方法回顾性分析本院2007年1月～2013年1月住院的58例初治AL患者，将其分为治疗组与对照组，治疗组给予氟康唑胶囊100mrCd，口服．自化疗开始至脱离粒细胞缺乏时停止；对照组未常规应用预防性抗真菌治疗。观察两组患者真菌感染率的差异。结果治疗组化疗后并发真菌感染率为7．4％（2／27），对照组并发真菌感染率为29．0％（9／31），差异有统计学意义（P〈0．05）。结论氟康唑预防性治疗对于预防初治AL患者真菌感染有显著疗效。

Clinical observation on prevention of fungal infection in primary acute leukemia with fluconazole

Objective To evaluate the efficacy of fluconazole for prevention of fungal infection in neutropenia patients with primary acute leukemia after chemotherapy.Methods Clinical data of 58 patients with acute leukemia in our hos- pital from January 2007 to January 2013 were retrospectively analyzed,all the patients were divided into treatment group and control group.Patients in treatment group received fluconazole （100 mg/d） after chemotherapy until out of neutropenic.The patients in control group were not received the prophylactic antifungal therapy.The difference of the incidence of fungal infection between the tow groups was observed. Results The rate of fungal infection in treatment group was 7.4%（2/27）,and 29.0%（9/31） in control group.The difference was statistically significant （P〈0.05）. Conclu- sion The prophylactic treatment with fluconazole can effectively reduce the incidence of fungal infections in neutrope- nia patients with acute leukemia after chemotherapy.